Ns-90z Plus Nanoparticle Size and Potential Analyzer

• Customization: Available
• After-sales Service: on Line Service
• Application: Laboratory Apparatus
• Model NO.: NS90Z
• Wavelengths: 0.3nm-5000nm (Subject to The Sample)
• Dispersive Element: Dynamic Light Scattering Method
• Light Number: Monochromator
• Certification: ISO9001, CE
• Customized: Customized
• Product Name: Nanometer Particle Size Analyzer
• Model: Ns90z
• Measurement Range: 0.3nm -15μm
• Accuracy: Better Than +-1%
• Repeatability: Better Than +-1%
• Minimum Sample Size: 3UL
• Measurement Angle: 90 ; for Paricle Size, 12degr; for Zeta Potential
• Temperature Control Range: 0c- 90c(120c Optional)
• Temperature Control Accuracy: +-0.1 C
• Condensing Control: Dry Air Blowing
• Particle Size Range Suitable for Zeta Po: 3nm – 100μm
• Molecular Weight Range: 340da - 2X107da
• Working Temperature: 5c-40c
• Weight: 17kg
• Dimensions: 365mm * 475mm * 180mm
• Transport Package: Wooden Case
• Specification: 365mm x 475mm x 180mm
• Trademark: NANBEI
• Origin: China
• HS Code: 9027300000
• Production Capacity: 50pieces/Month

Product Description

NS-90Z Plus Nanoparticle Size and Potential Analyzer
 

Product Description

Introduction:

NS-90Z Plus nanoparticle size and potential analyzer is a new product developed by Nanbei Instrument after successfully introducing Malvern Panalytical's nanoparticle characterization technology. It further optimizes the optical electronic measurement technology and analytical performance based on the previous generation NS-90Z. NS-90Z Plus has more superior particle size and potential analysis functions, and can meet the particle size and Zeta potential testing needs of a large number of users in nanomaterial, formulation development and production.


NS-90Z Plus nanoparticle size and potential analyzer uses dynamic light scattering technology to measure the particle size of particles and granules, electrophoretic light scattering technology to determine the particle Zeta potential and potential distribution, and static light scattering technology to determine the molecular weight of proteins and polymers. NS-90Z Plus integrates Malvern Panalytical's M3-PALS fast and slow field mixed phase detection analysis technology in constant flow mode, which improves the instrument's potential analysis performance, upgrades the compatible microcapillary sample cell (optional) function, and significantly improves the concentration and particle size range of analyzable samples.
At the same time, the instrument widely adopts high-quality optoelectronic components from the global supply chain and the Scrum software iterative upgrade development model, making it high-quality and able to upgrade management and reporting functions as user needs change. 

Working Principle
NS-90Z Plus nanoparticle size and potential analyzer integrates three testing technologies in one compact instrument:
Dynamic Light Scattering Technology
NS-90Z Plus nanoparticle size and potential analyzer uses the classic 90° angle dynamic light scattering (DLS) technology to measure the particle and granule size. This technology uses a photodetector to measure the scattered light intensity fluctuation signal generated by the Brownian motion of particles in the sample, and calculates the correlation function (Correlation Function) through a digital correlator to analyze the diffusion rate of the particles, and then calculates the particle size and distribution of the particles using the Stokes-Einstein equation. The particle size measured by this technology is the hydrodynamic equivalent diameter, which is calculated by the equivalent diameter of a hard sphere with the same diffusion rate. Dynamic light scattering is also called Photon Correlation Spectroscopy (PCS).


                                      NS-90Z Plus dynamic light scattering optical path diagram


Electrophoretic Light Scattering Technology
NS-90Z Plus uses electrophoretic light scattering (ELS) technology to measure the Zeta potential of the particle slip layer. Particles move electrophoretically under the action of an artificially applied electric field, and their electrophoretic movement rate is directly related to the Zeta potential, which is described by the Henry equation. NS-90Z Plus uses the fast and slow field mixed laser Doppler phase analysis method (Mixed mode measurement, phase analysis light scattering/M3-PALS) in constant current mode to successfully solve the impact of capillary electroosmosis on the test, and obtain the Zeta potential average value and potential distribution curve in one test. Electrophoretic light scattering technology can measure the Zeta potential of samples with a maximum particle size of about 100μm (depending on the sample properties and preparation).

         Conceptual diagram of Zeta potential

NS-90Z Plus electrophoretic light scattering optical path diagram


Static Light Scattering Technology
NS-90Z Plus nanoparticle size and potential analyzer uses static light scattering (SLS) technology to non-invasively characterize the molar mass, i.e. molecular weight, of particles such as protein monomers, aggregates or polymers in solutions and colloids. In the description of the Debye method for molecular weight calculation, the intensity of scattered light generated by the particles is proportional to the square of the weight-average molecular weight and the particle concentration. By using the Debye method to measure the static scattered light intensity of a set of samples with a concentration gradient, the molecular weight of proteins and polymers can be calculated. Unlike dynamic light scattering technology, static light scattering technology measures the average intensity of scattered light over a period of time. The unit of molecular weight is Da (Dalton) or g/mol.




NS-90Z Plus static light scattering Debye plot analysis of nanoparticle molecular weight

Applications
NS-90Z Plus nanoparticle size and potential analyzer is a cost-effective instrument for characterizing nanoparticle size and nano-micron particle Zeta potential. It is suitable for material analysis with high sensitivity requirements for particle size and potential distribution characterization, as well as applications that require the same results as the 90 scattering angle particle size test system. The instrument is suitable for testing and analyzing samples such as molecules, proteins, polymers, colloids, emulsions, suspensions, and various complex formulation systems.
Typical Applications
• Characterization of colloids and emulsions
• Formulation and process development of medicine dispersion systems, emulsions and vaccines
• Development of liposomes and vesicles
• Evaluation of proteins and their aggregates
• Characterization of particle size, dispersion and stability of electrode slurries and additives
• Prediction of dispersion properties of coating materials
• Modification of high conductivity sols such as nanogold
• Improvement of ink, toner, dye and pigment performance
• Optimization of the use of flocculants in water treatment
• Evaluation of the stability of colloids, emulsions and slurries
• Determination of processing parameters such as mixing and homogenization of various complex preparations


Performance Characteristics
Advanced high signal-to-noise ratio optical design
NS-90Z Plus nanoparticle size and potential analyzer integrates three optical principle technologies: electrophoretic light scattering, dynamic light scattering, and static light scattering in one compact instrument. Through optimized optical design, fiber optic transmission design, and high-performance light source, signal acquisition and processing hardware, the scattered light signal recognition capability is improved and stray light interference is reduced, ensuring high accuracy, sensitivity, and reproducibility of the instrument test results, and expanding the range of suitable sample tests.

Easy-to-use, maintenance-free system design
NS-90Z Plus adopts a closed optical path design to prevent contamination, and the main unit does not require maintenance during daily use. It uses a replaceable variety of optional cuvette sample pools, which are easy to use and can prepare multiple samples at the same time for sequential testing, which is more efficient. The sample pool can also be cleaned and reused, without the need for complex instrument or detection device maintenance.

Gas laser light source with high optical performance, stability and long life

Imported high-stability He-Ne gas laser is used to ensure data reproducibility, with a wavelength of 632.8nm and a power of 4mW. The beam divergence angle, monochromaticity, temperature and voltage fluctuation stability, and coherence of He-Ne gas lasers are far superior to semiconductor solid lasers. The gas laser tube used in NS-90Z Plus adopts a hard packaging process to ensure that the inert working material of helium-neon gas in the laser tube is not lost for life. The life of the laser tube reaches more than 10 years, and its optical quality hardly changes during its life cycle, ensuring that the test data is always reliable and no user calibration is required. Because the coherence performance of He-Ne gas lasers is significantly better than that of semiconductor solid lasers, only lower power is required to generate scattered light signals that meet measurement requirements, and lower stray light noise makes sample analysis more sensitive. The instrument can adaptively adjust the laser intensity through an attenuator within a dynamic range of 330000:1.
Reports can be customized with multiple parameters
NS-90Z Plus has complete nanoparticle size and Zeta potential analysis functions. It can output parameters such as Z average diameter, polydispersity index PI, peak particle size and content of each particle size distribution peak, and can also output volume and number distribution (using full-range Mie Theory calculation). It can output parameters such as Zeta potential and potential distribution.



High-performance detector
Use high quantum efficiency (QE) avalanche photodiode (APD) detector, QE ≥ 80% @ 632.8nm, with much higher sensitivity than photomultiplier tube (PMT) and lower noise. High-cost high-quality APD components ensure excellent test performance of the instrument.




Research-grade digital correlator
Using high-speed digital correlator, more than 4000 channels, 1011 dynamic linear range, the shortest sampling time interval can be as low as 25ns, combined with advanced correlation algorithm, the shortest sub-measurement time can be shortened to 1.68s.




Precise internal temperature control system
The independent Peltier cycle temperature control device can be set arbitrarily within the range of 0-120ºC, with fast heating and cooling speeds, and the control accuracy can reach up to 0.1ºC, ensuring high reproducibility of test results.
M3-PALS fast and slow field mixed phase detection technology in constant current mode
In addition to eliminating the influence of electroosmosis, NS-90Z Plus integrates Malvern's M3-PALS technology. The newly upgraded constant current mode also makes it possible to test samples with higher conductivity. The constant current mode can effectively alleviate the influence of electrode polarization. Together with the switchable high-frequency and low-frequency mixed analysis mode, the results are more reproducible, more accurate, and information on potential distribution can be obtained. Compared with the previous generation of products, the NS-90Z Plus can meet the Zeta potential and electrophoretic mobility tests of samples with higher conductivity, and can also increase the number of times the potential sample cell can be used.

Fast and slow field mixed phase detection Zeta potential distribution, phase, frequency shift and Zeta voltage and current diagram


Upgraded expert guidance function improves test level
After testing, the NS-90Z Plus will automatically generate intelligent expert guidance under the data quality guidance module to provide feasible solutions for further optimizing the test or sample processing. This technology can simultaneously assist users to quickly interpret more accurate particle size, Zeta potential and potential distribution results, which is conducive to reducing test data errors and timely discovering and improving test quality changes caused by changes in methods or environment.




It has audit, authority management and electronic signature functions that meet the requirements of CFDA GMP "Computerized System and Confirmation and Validation"

User rights configuration and management function diagram


Audit trail function diagram

Feature-rich software optimizes user experience
Provides standardized operating procedures (SOPs) to simplify routine measurements; automatically configures the best hardware and algorithm settings for various samples, and can also be set manually; simple to operate, no alignment, calibration or additional maintenance required; intelligent, can automatically determine the quality of data reports and provide optimization suggestions.
1. Using the advanced SCRUM software iterative development model, the novel interface design based on the current mainstream software development technology is simple and easy to use, and the software can be continuously upgraded to match the industry applications and regulatory changes.
2. Fully automatic hardware setup and measurement: Only the simplest training is required to set up the instrument, including sample pool position, data recording, analysis and result display.

Potential test setup interface (part) and analysis model selection diagram

 

3.Support SOP standardized operating procedures to avoid inconsistencies in test operations and parameter settings, thereby improving data reproducibility.

4.Intelligent system evaluation of measurement data: The instrument analysis software can automatically and intelligently judge the quality of the data report based on the test conditions and results, and give improvement suggestions for poor quality tests. It includes the quality evaluation of the test report, the cause of the problem, how to use the data, how to improve the data, etc.

5.Printing or screen display reports are easy to use; with a report designer, you only need to select the required result chart in the specified location to customize different reports according to different needs.

 

1. 6.Sample data and results are stored in measurement files to facilitate data comparison.

7.Data analysis: Data is presented in the form of graphs or tables and can be exported with one click; a variety of analysis modes are available to suit a variety of sample tests including monodisperse samples and broad distribution samples; it has a variety of data classification, grouping, sorting, screening, statistics and trend analysis functions.

 

8.It has a complete medium viscosity database and can automatically calculate the viscosity of common buffer systems based on a given temperature.

Typical test results

1. NS-90Z Plus has good reproducibility - 60nm latex microsphere standard (Thermal, nominal value: 62±3nm)
2. NS-90Z Plus improves the performance of particle size upper limit analysis - testing of 10μm standard samples*
3. NS-90Z Plus excellent resolution - 60nm, 200nm dual standard mixed sample
4. Measurement of NS-90Z Plus potential and potential distribution - ZTS1240 potential standard
5.  
6. Standard accessories:
7. 12mm square polystyrene sample cell (DTS0012) 
   Replaceable, pollution-free
   Minimum sample volume 1mL
   Suitable for particle size testing with water or ethanol as dispersion medium
   It can be used with the universal "plug-in" sample cell kit (ZEN1002) for Zeta potential testing 
8. Folding capillary sample cell (DTS1070)
   Replaceable, pollution-free
   When using the diffusion barrier method, the minimum sample volume of 20μL can be tested
   Suitable for Zeta potential testing with water or ethanol as the dispersion medium
   It can use a standardized micro-permeable Luer taper and use it with the MPT-3 automatic titrator (ZSU1001)
   Can be used to test hundreds of low conductivity samples in constant current model 
9. 2mm square glass sample cell (PCS8501)
10. Minimum sample volume 1mL
    Made of glass, suitable for testing most aqueous or non-aqueous solvents/media

Optional accessories:
Microcapillary sample pool (ZSU1002)
Consists of a sample pool base and replaceable square microcapillary
Minimum sample volume 3μL
It can more accurately test particles larger than 1μm
Particle size measurement upper limit can be extended to 15μm
Universal "plug-in" sample cell kit (ZEN1002)
Minimum sample volume 0.7mL
It can be used with 12mm square polystyrene sample cell (DTS0012) for testing aqueous samples
It can be used with 12mm glass sample cell (PCS1115) for testing aqueous or non-aqueous samples
Easy to prepare multiple samples at the same time, speeding up the testing process

High concentration Zeta potential sample cell kit (ZEN1010)
Suitable for testing water-based samples that cannot be diluted or have high concentrations
It can be used with the MPT-3 automatic titrator (ZSU1001)

12mm glass sample cell (PCS1115)
Minimum sample volume 1mL
Glass material, suitable for testing most aqueous and non-aqueous solvents or media
It can be used with the universal "plug-in" sample cell kit (ZEN1002) for Zeta potential testing
Low-capacity quartz sample cell (ZEN2112)
Made of quartz, suitable for testing most aqueous and non-aqueous solvents or media

MPT-3 automatic titrator (ZSU1001)
Minimum sample volume 5mL
Titrant accuracy 0.28μL
Suitable for testing aqueous samples
It can automatically titrate pH value and test particle size and Zeta potential that change with pH value
It can measure isopotential to evaluate the stability of dispersed systems
 

Product Parameters

Particle size
1. Measurement range*: 0.3nm - 10μm (depending on the sample)
2. Measurement principle: Dynamic light scattering (DLS)
3. Repeatability error: ≤ 1% (NIST traceable latex standard)
4. Minimum sample volume*: 20µL
5. Minimum sample concentration: ≤ 1mg/mL (depending on the sample)
6. Maximum sample concentration: 40% w/v (depending on the sample)
7. Minimum subtest time: 1.68s
Molecular weight
8. Molecular weight measurement range: 980 - 2×107 Da (depending on the sample), Debye method
342 - 2×107 Da (depending on the sample), DLS calculation

1. Measurement principle: Static light scattering (SLS) Debye method and dynamic light scattering (DLS) calculation

Zeta potential
10. Zeta potential range: no practical limit
11. Upper limit of particle size applicable for testing: not less than 100μm (depending on the sample)
12. Maximum electrophoretic rate: >+20μ.cm/V.s / <-20μ.cm>
13. Measurement principle: electrophoretic light scattering (ELS)
14. Maximum sample concentration: 40% w/v (depending on the sample)
15. Minimum sample volume: 20μL
16. Maximum sample conductivity: 260mS/cm
17. Detection technology: fast and slow field mixed mode phase analysis (M3-PALS), constant current mode
System
18. Laser source: High-stable He-Ne gas laser, wavelength 632.8nm, power 4mW.
19. Laser safety of the whole machine: Class I
20. Detection angle: 90, 13
21. Detector: Avalanche photodiode (APD) detector, QE>80%@632.8nm
22. Correlator: Sampling time 25ns - 8000s, more than 4000 channels, 1011 dynamic linear range
23. Condensation control: Dry nitrogen or air purge (external gas source required)
24. Audit, authority management and electronic signature functions compatible with CFDA GMP "Computerized System and Confirmation and Validation"
25. Temperature control range: 0 - 120 ºC
26. Maximum temperature control accuracy: ± 0.1 ºC
Weight and size
27. Host size: 322×565×245 mm (W×D×H)
28. Host net weight: 19 kg
Operating environment
29. Power requirements: AC 100 - 240V, 50 - 60Hz, 4.0A
30. Power: maximum 100W, typical 45W
31. Recommended minimum computer configuration: Intel Core i5 2.5Ghz and above, 4GB memory, 250G hard disk, display resolution 1440×900 32bit and above
32. Computer interface: USB 2.0 or higher
33. Recommended operating system: Windows 10 or Windows 11 Professional Edition
Environmental requirements: temperature 10 - 35ºC, humidity: 35 - 80%, no condensation

*The optional microcapillary sample pool extends the particle size analysis limit to samples with a particle size of 15μm, with a minimum sample volume of only 3μL.
**Although we have made every effort to ensure the accuracy and completeness of the information in this material, we reserve the right to change any content in this material at any time.

 

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FAQ

1. How can I choose the suitable one?
Dear customer, please tell us your detailed requirements by mail or online, we will recommend the suitable one as your request.
2. Does your price is competitive?
Dear customer, we make sure to offer you the best quality with competitive price.
3. How can I pay?
Dear customer, we accept many payment term, such as T/T, Western Union…
4. When I receive it after pay?
Dear customer, normal models can be delivered with 5-7days, please contact us to check transport time to your address.
5. How to deliver?
Dear customer, we can send by Express, by Sea and by Air.
6. Is will be broken during transport?
Dear customer, please do not worry, we do standard export package.
7. What should I do if I do not know how to use?
Dear customer, please do not worry, manual user will be sent together, you can also contact us with more technological support.
8. What should I do if some parts broken?
Dear customer, please do not worry, we have 12months warranty except  wear parts. You can also buy parts from us after 12months.

Pre-sale service
· 24hours online to ensure quick response to customers' inquiry or online message;
· Guide customers to choose the best suitable machine model;
· Offer detailed specification and competitive prices;
Contract execution
· Machine production will be arranged strictly according to the contract;
· Machine photos will be sent to you for inspection during production;
· Send customs clearance documents by DHL;
· Update latest news after delivery and prepare customs clearance;
After-sale service
· 12 months warranty except for wear parts;
· Broken spare parts (except for wear parts) will be sent for free due to quality problems;
· In time response to customers technical problems;
· New products update for customers' reference.